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Integrin αIIbβ3 outside-in signaling activates human platelets through serine 24 phosphorylation of Disabled-2

BACKGROUND: Bidirectional integrin αIIbβ3 signaling is essential for platelet activation. The platelet adaptor protein Disabled-2 (Dab2) is a key regulator of integrin signaling and is phosphorylated at serine 24 in eukaryotic cells. However, the mechanistic insight and function of Dab2-serine 24 ph...

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Detalles Bibliográficos
Autores principales:	Tsai, Hui-Ju, Cheng, Ju-Chien, Kao, Man-Leng, Chiu, Hung-Pin, Chiang, Yi-Hsuan, Chen, Ding-Ping, Rau, Kun-Ming, Liao, Hsiang-Ruei, Tseng, Ching-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869483/ https://www.ncbi.nlm.nih.gov/pubmed/33557943 http://dx.doi.org/10.1186/s13578-021-00532-5

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