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Structure-aware protein solubility prediction from sequence through graph convolutional network and predicted contact map

Protein solubility is significant in producing new soluble proteins that can reduce the cost of biocatalysts or therapeutic agents. Therefore, a computational model is highly desired to accurately predict protein solubility from the amino acid sequence. Many methods have been developed, but they are...

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Detalles Bibliográficos
Autores principales: Chen, Jianwen, Zheng, Shuangjia, Zhao, Huiying, Yang, Yuedong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869490/
https://www.ncbi.nlm.nih.gov/pubmed/33557952
http://dx.doi.org/10.1186/s13321-021-00488-1