Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT

BACKGROUND: TIGIT, as a novel immune checkpoint molecule involved in T cell and NK cell anergy, could induce the immune tolerance and escape through binding with its ligand PVR. Blockade of TIGIT/PVR is considered as a promising strategy in cancer immunotherapy. However, to facilitate the design of...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaowen, Du, Jiangfeng, Zhou, Xiuman, Niu, Xiaoshuang, Li, Wanqiong, Chen, Chunxia, Lv, Sifan, Wu, Aijun, Gou, Shanshan, Sun, Yixuan, Zhai, Wenjie, Qiu, Lu, Qi, Yuanming, Zhao, Wenshan, Gao, Yanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869511/
https://www.ncbi.nlm.nih.gov/pubmed/33557880
http://dx.doi.org/10.1186/s12964-020-00701-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869511/
https://www.ncbi.nlm.nih.gov/pubmed/33557880
http://dx.doi.org/10.1186/s12964-020-00701-y

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