Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma

Melanoma tumors driven by BRAF mutations often do not respond to BRAF/MEK/ERK pathway inhibitors currently used in treatment. One documented mechanism of resistance is upregulation of SOX2, a transcription factor that is essential for tumor growth and expansion, particularly in melanoma tumors with...

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Detalles Bibliográficos
Autores principales: Potu, Harish, Kandarpa, Malathi, Peterson, Luke F., Durham, Alison, Donato, Nicholas J., Talpaz, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869572/
https://www.ncbi.nlm.nih.gov/pubmed/33613844
http://dx.doi.org/10.18632/oncotarget.27869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869572/
https://www.ncbi.nlm.nih.gov/pubmed/33613844
http://dx.doi.org/10.18632/oncotarget.27869

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