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Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma
Melanoma tumors driven by BRAF mutations often do not respond to BRAF/MEK/ERK pathway inhibitors currently used in treatment. One documented mechanism of resistance is upregulation of SOX2, a transcription factor that is essential for tumor growth and expansion, particularly in melanoma tumors with...
Autores principales: | Potu, Harish, Kandarpa, Malathi, Peterson, Luke F., Durham, Alison, Donato, Nicholas J., Talpaz, Moshe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869572/ https://www.ncbi.nlm.nih.gov/pubmed/33613844 http://dx.doi.org/10.18632/oncotarget.27869 |
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