Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis

During vesicular acidification, chloride (Cl(−)), as the counterion, provides the electrical shunt for proton pumping by the vacuolar H(+) ATPase. Intracellular CLC transporters mediate Cl(−) influx to the endolysosomes through their 2Cl(−)/H(+) exchange activity. However, whole-endolysosomal patch-...

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Detalles Bibliográficos
Autores principales: Osei-Owusu, James, Yang, Junhua, Leung, Ka Ho, Ruan, Zheng, Lü, Wei, Krishnan, Yamuna, Qiu, Zhaozhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869721/
https://www.ncbi.nlm.nih.gov/pubmed/33503418
http://dx.doi.org/10.1016/j.celrep.2020.108683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869721/
https://www.ncbi.nlm.nih.gov/pubmed/33503418
http://dx.doi.org/10.1016/j.celrep.2020.108683

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