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Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
During vesicular acidification, chloride (Cl(−)), as the counterion, provides the electrical shunt for proton pumping by the vacuolar H(+) ATPase. Intracellular CLC transporters mediate Cl(−) influx to the endolysosomes through their 2Cl(−)/H(+) exchange activity. However, whole-endolysosomal patch-...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869721/ https://www.ncbi.nlm.nih.gov/pubmed/33503418 http://dx.doi.org/10.1016/j.celrep.2020.108683 |