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Mathematical modelling of oxygen gradients in stem cell-derived liver tissue

A major bottleneck in the study of human liver physiology is the provision of stable liver tissue in sufficient quantity. As a result, current approaches to modelling human drug efficacy and toxicity rely heavily on immortalized human and animal cell lines. These models are informative but do posses...

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Detalles Bibliográficos
Autores principales: Leedale, Joseph A., Lucendo-Villarin, Baltasar, Meseguer-Ripolles, Jose, Kasarinaite, Alvile, Webb, Steven D., Hay, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870006/
https://www.ncbi.nlm.nih.gov/pubmed/33556073
http://dx.doi.org/10.1371/journal.pone.0244070