Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength

The conserved MAP3K Dual-Leucine-Zipper Kinase (DLK) and Leucine-Zipper-bearing Kinase (LZK) can activate JNK via MKK4 or MKK7. These two MAP3Ks share similar biochemical activities and undergo auto-activation upon increased expression. Depending on cell-type and nature of insults DLK and LZK can in...

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Detalles Bibliográficos
Autores principales: Li, Yunbo, Ritchie, Erin M, Steinke, Christopher L, Qi, Cai, Chen, Lizhen, Zheng, Binhai, Jin, Yishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870138/
https://www.ncbi.nlm.nih.gov/pubmed/33475086
http://dx.doi.org/10.7554/eLife.63509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870138/
https://www.ncbi.nlm.nih.gov/pubmed/33475086
http://dx.doi.org/10.7554/eLife.63509

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