Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

We generated induced excitatory neurons (iNeurons, iNs) from chimpanzee, bonobo, and human stem cells by expressing the transcription factor neurogenin-2 (NGN2). Single-cell RNA sequencing showed that genes involved in dendrite and synapse development are expressed earlier during iNs maturation in t...

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Detalles Bibliográficos
Autores principales: Schörnig, Maria, Ju, Xiangchun, Fast, Luise, Ebert, Sebastian, Weigert, Anne, Kanton, Sabina, Schaffer, Theresa, Nadif Kasri, Nael, Treutlein, Barbara, Peter, Benjamin Marco, Hevers, Wulf, Taverna, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870144/
https://www.ncbi.nlm.nih.gov/pubmed/33470930
http://dx.doi.org/10.7554/eLife.59323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870144/
https://www.ncbi.nlm.nih.gov/pubmed/33470930
http://dx.doi.org/10.7554/eLife.59323

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