SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C-terminally truncated form of MRE11 (TR-MRE11) associate...

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Detalles Bibliográficos
Autores principales: Na, Juri, Newman, Joseph A., Then, Chee Kin, Syed, Junetha, Vendrell, Iolanda, Torrecilla, Ignacio, Ellermann, Sophie, Ramadan, Kristijan, Fischer, Roman, Kiltie, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870818/
https://www.ncbi.nlm.nih.gov/pubmed/33558481
http://dx.doi.org/10.1038/s41419-021-03437-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870818/
https://www.ncbi.nlm.nih.gov/pubmed/33558481
http://dx.doi.org/10.1038/s41419-021-03437-w

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