Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers

There are only few data concerning persistence of neutralizing antibodies (NAbs) among SARS-CoV-2-infected healthcare workers (HCW). These individuals are particularly exposed to SARS-CoV-2 infection and at potential risk of reinfection. We followed 26 HCW with mild COVID-19 three weeks (D21), two m...

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Autores principales: Marot, Stéphane, Malet, Isabelle, Leducq, Valentin, Zafilaza, Karen, Sterlin, Delphine, Planas, Delphine, Gothland, Adélie, Jary, Aude, Dorgham, Karim, Bruel, Timothée, Burrel, Sonia, Boutolleau, David, Schwartz, Olivier, Gorochov, Guy, Calvez, Vincent, Marcelin, Anne-Geneviève
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870823/
https://www.ncbi.nlm.nih.gov/pubmed/33558507
http://dx.doi.org/10.1038/s41467-021-21111-9
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author Marot, Stéphane
Malet, Isabelle
Leducq, Valentin
Zafilaza, Karen
Sterlin, Delphine
Planas, Delphine
Gothland, Adélie
Jary, Aude
Dorgham, Karim
Bruel, Timothée
Burrel, Sonia
Boutolleau, David
Schwartz, Olivier
Gorochov, Guy
Calvez, Vincent
Marcelin, Anne-Geneviève
author_facet Marot, Stéphane
Malet, Isabelle
Leducq, Valentin
Zafilaza, Karen
Sterlin, Delphine
Planas, Delphine
Gothland, Adélie
Jary, Aude
Dorgham, Karim
Bruel, Timothée
Burrel, Sonia
Boutolleau, David
Schwartz, Olivier
Gorochov, Guy
Calvez, Vincent
Marcelin, Anne-Geneviève
author_sort Marot, Stéphane
collection PubMed
description There are only few data concerning persistence of neutralizing antibodies (NAbs) among SARS-CoV-2-infected healthcare workers (HCW). These individuals are particularly exposed to SARS-CoV-2 infection and at potential risk of reinfection. We followed 26 HCW with mild COVID-19 three weeks (D21), two months (M2) and three months (M3) after the onset of symptoms. All the HCW had anti-receptor binding domain (RBD) IgA at D21, decreasing to 38.5% at M3 (p < 0.0001). Concomitantly a significant decrease in NAb titers was observed between D21 and M2 (p = 0.03) and between D21 and M3 (p < 0.0001). Here, we report that SARS-CoV-2 can elicit a NAb response correlated with anti-RBD antibody levels. However, this neutralizing activity declines, and may even be lost, in association with a decrease in systemic IgA antibody levels, from two months after disease onset. This short-lasting humoral protection supports strong recommendations to maintain infection prevention and control measures in HCW, and suggests that periodic boosts of SARS-CoV-2 vaccination may be required.
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spelling pubmed-78708232021-02-11 Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers Marot, Stéphane Malet, Isabelle Leducq, Valentin Zafilaza, Karen Sterlin, Delphine Planas, Delphine Gothland, Adélie Jary, Aude Dorgham, Karim Bruel, Timothée Burrel, Sonia Boutolleau, David Schwartz, Olivier Gorochov, Guy Calvez, Vincent Marcelin, Anne-Geneviève Nat Commun Article There are only few data concerning persistence of neutralizing antibodies (NAbs) among SARS-CoV-2-infected healthcare workers (HCW). These individuals are particularly exposed to SARS-CoV-2 infection and at potential risk of reinfection. We followed 26 HCW with mild COVID-19 three weeks (D21), two months (M2) and three months (M3) after the onset of symptoms. All the HCW had anti-receptor binding domain (RBD) IgA at D21, decreasing to 38.5% at M3 (p < 0.0001). Concomitantly a significant decrease in NAb titers was observed between D21 and M2 (p = 0.03) and between D21 and M3 (p < 0.0001). Here, we report that SARS-CoV-2 can elicit a NAb response correlated with anti-RBD antibody levels. However, this neutralizing activity declines, and may even be lost, in association with a decrease in systemic IgA antibody levels, from two months after disease onset. This short-lasting humoral protection supports strong recommendations to maintain infection prevention and control measures in HCW, and suggests that periodic boosts of SARS-CoV-2 vaccination may be required. Nature Publishing Group UK 2021-02-08 /pmc/articles/PMC7870823/ /pubmed/33558507 http://dx.doi.org/10.1038/s41467-021-21111-9 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Marot, Stéphane
Malet, Isabelle
Leducq, Valentin
Zafilaza, Karen
Sterlin, Delphine
Planas, Delphine
Gothland, Adélie
Jary, Aude
Dorgham, Karim
Bruel, Timothée
Burrel, Sonia
Boutolleau, David
Schwartz, Olivier
Gorochov, Guy
Calvez, Vincent
Marcelin, Anne-Geneviève
Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers
title Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers
title_full Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers
title_fullStr Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers
title_full_unstemmed Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers
title_short Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers
title_sort rapid decline of neutralizing antibodies against sars-cov-2 among infected healthcare workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870823/
https://www.ncbi.nlm.nih.gov/pubmed/33558507
http://dx.doi.org/10.1038/s41467-021-21111-9
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