Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

A concept of polyclonal metastasis has recently been proposed, wherein tumor cell clusters break off from the primary site and are disseminated. However, the involvement of driver mutations in such polyclonal mechanism is not fully understood. Here, we show that non-metastatic AP cells metastasize t...

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Detalles Bibliográficos
Autores principales: Kok, Sau Yee, Oshima, Hiroko, Takahashi, Kei, Nakayama, Mizuho, Murakami, Kazuhiro, Ueda, Hiroki R., Miyazono, Kohei, Oshima, Masanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870854/
https://www.ncbi.nlm.nih.gov/pubmed/33558489
http://dx.doi.org/10.1038/s41467-021-21160-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870854/
https://www.ncbi.nlm.nih.gov/pubmed/33558489
http://dx.doi.org/10.1038/s41467-021-21160-0

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