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Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation
A concept of polyclonal metastasis has recently been proposed, wherein tumor cell clusters break off from the primary site and are disseminated. However, the involvement of driver mutations in such polyclonal mechanism is not fully understood. Here, we show that non-metastatic AP cells metastasize t...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870854/ https://www.ncbi.nlm.nih.gov/pubmed/33558489 http://dx.doi.org/10.1038/s41467-021-21160-0 |