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Effects of individual base-pairs on in vivo target search and destruction kinetics of bacterial small RNA
Base-pairing interactions mediate many intermolecular target recognition events. Even a single base-pair mismatch can cause a substantial difference in activity but how such changes influence the target search kinetics in vivo is unknown. Here, we use high-throughput sequencing and quantitative supe...
Autores principales: | Poddar, Anustup, Azam, Muhammad S., Kayikcioglu, Tunc, Bobrovskyy, Maksym, Zhang, Jichuan, Ma, Xiangqian, Labhsetwar, Piyush, Fei, Jingyi, Singh, Digvijay, Luthey-Schulten, Zaida, Vanderpool, Carin K., Ha, Taekjip |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870926/ https://www.ncbi.nlm.nih.gov/pubmed/33558533 http://dx.doi.org/10.1038/s41467-021-21144-0 |
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