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Mechanism of the small ATP-independent chaperone Spy is substrate specific

ATP-independent chaperones are usually considered to be holdases that rapidly bind to non-native states of substrate proteins and prevent their aggregation. These chaperones are thought to release their substrate proteins prior to their folding. Spy is an ATP-independent chaperone that acts as an ag...

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Detalles Bibliográficos
Autores principales: Mitra, Rishav, Gadkari, Varun V., Meinen, Ben A., van Mierlo, Carlo P. M., Ruotolo, Brandon T., Bardwell, James C. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870927/
https://www.ncbi.nlm.nih.gov/pubmed/33558474
http://dx.doi.org/10.1038/s41467-021-21120-8