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Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

Cell entry of the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated by its spike protein S. As a main antigenic determinant, S protein is in focus of various therapeutic strategies. Besides particle-cell fusion, S mediates fusion between infected and uninfected cells...

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Detalles Bibliográficos
Autores principales: Theuerkauf, Samuel A., Michels, Alexander, Riechert, Vanessa, Maier, Thorsten J., Flory, Egbert, Cichutek, Klaus, Buchholz, Christian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871100/
https://www.ncbi.nlm.nih.gov/pubmed/33585805
http://dx.doi.org/10.1016/j.isci.2021.102170