Inhibition of Ref(2)P, the Drosophila homologue of the p62/SQSTM1 gene, increases lifespan and leads to a decline in motor function

OBJECTIVE: Sequestosome 1 (p62/SQSTM1) is a multifunctional scaffold/adaptor protein encoded by the p62/SQSTM1 gene with function in cellular homeostasis. Mutations in the p62/SQSTM1 gene have been known to be associated with patients with amyotrophic lateral sclerosis (ALS), frontotemporal dementia...

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Detalles Bibliográficos
Autores principales: Hurley, Emily P., Staveley, Brian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871602/
https://www.ncbi.nlm.nih.gov/pubmed/33557921
http://dx.doi.org/10.1186/s13104-021-05462-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871602/
https://www.ncbi.nlm.nih.gov/pubmed/33557921
http://dx.doi.org/10.1186/s13104-021-05462-6

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