Cargando…

A poly-ADP-ribose polymer-based antibody-drug conjugate

Protein poly-ADP-ribosylation (PARylation) plays vital roles in many aspects of physiology and pathophysiology. This posttranslational modification is catalyzed by poly-ADP-ribose polymerases (PARPs) through additions of ADP-ribose from nicotinamide adenine dinucleotide (NAD(+)) to protein residues,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Xiaojing, Zhang, Xiao-Nan, Chen, Jingwen, Cheng, Qinqin, Pei, Hua, Louie, Stan G., Zhang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871713/ https://www.ncbi.nlm.nih.gov/pubmed/33623656 http://dx.doi.org/10.1039/d0sc01795g

Ejemplares similares

A ribose-functionalized NAD(+) with unexpected high activity and selectivity for protein poly-ADP-ribosylation
por: Zhang, Xiao-Nan, et al.
Publicado: (2019)

Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases
por: Dai, Zhefu, et al.
Publicado: (2020)

Telomerase and poly(ADP-ribose) polymerase-1 activity sensing based on the high fluorescence selectivity and sensitivity of TOTO-1 towards G bases in single-stranded DNA and poly(ADP-ribose)
por: Yang, Haitang, et al.
Publicado: (2019)

Nanoparticle Formulations of Poly (ADP-ribose) Polymerase Inhibitors for Cancer Therapy
por: Singh, Bijay, et al.
Publicado: (2020)

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers
por: Tesauro, Cinzia, et al.
Publicado: (2014)

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes
por: Gagné, Jean-Philippe, et al.
Publicado: (2008)

Poly(ADP-ribose): An organizer of cellular architecture
por: Leung, Anthony K.L.
Publicado: (2014)

Poly (ADP-ribose) in the pathogenesis of Parkinson's disease
por: Lee, Yunjong, et al.
Publicado: (2014)

RNA regulation by Poly(ADP-ribose) polymerases
por: Bock, Florian J., et al.
Publicado: (2015)

Oncogenic activity of poly (ADP-ribose) glycohydrolase
por: Marques, Maud, et al.
Publicado: (2018)

Mitotic functions of poly(ADP-ribose) polymerases
por: Slade, Dea
Publicado: (2019)

The Antiviral Activities of Poly-ADP-Ribose Polymerases
por: Malgras, Mathilde, et al.
Publicado: (2021)

Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents
por: Matanes, Emad, et al.
Publicado: (2021)

Stability of centrosome numbers in poly(ADP-ribose) polymerase-1- and poly(ADP-ribose) glycohydrolase-deficient mouse ES cells
por: Ogino, Hideki, et al.
Publicado: (2004)

Influence of chain length and branching on poly(ADP-ribose)–protein interactions
por: Löffler, Tobias, et al.
Publicado: (2023)

Nudix hydrolases degrade protein-conjugated ADP-ribose
por: Daniels, Casey M., et al.
Publicado: (2015)

Molecular Insights into Poly(ADP-ribose) Recognition and Processing
por: Žaja, Roko, et al.
Publicado: (2012)

Poly(ADP-ribose) polymerase inhibitors in Ewing sarcoma
por: Vormoor, Britta, et al.
Publicado: (2014)

The Sound of Silence: RNAi in Poly (ADP-Ribose) Research
por: Blenn, Christian, et al.
Publicado: (2012)

Role of poly(ADP-ribose) polymerases in male reproduction
por: Celik-Ozenci, Ciler, et al.
Publicado: (2013)

Readers of poly(ADP-ribose): designed to be fit for purpose
por: Teloni, Federico, et al.
Publicado: (2016)

Genetically Encoded Fluorescent Sensor for Poly-ADP-Ribose
por: Serebrovskaya, Ekaterina O., et al.
Publicado: (2020)

Poly(ADP-ribose) potentiates ZAP antiviral activity
por: Xue, Guangai, et al.
Publicado: (2022)

Pancreatic β-Cell Death, Regeneration and Insulin Secretion: Roles of Poly(ADP-Ribose) Polymerase and Cyclic ADP-Ribose
por: Takasawa, Shin, et al.
Publicado: (2002)

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
por: Dahl, Markus, et al.
Publicado: (2014)

Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP-ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells
por: FENG, XIAOXING, et al.
Publicado: (2012)

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy
por: Harrision, Daniel, et al.
Publicado: (2020)

New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases
por: Ryu, Keun Woo, et al.
Publicado: (2015)

Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis
por: Jiang, Bo-Hua, et al.
Publicado: (2015)

Loss of amplified genes by poly(ADP-ribose) polymerase inhibitors.
por: Nagao, M, et al.
Publicado: (1991)

Targeting poly(ADP-ribose) polymerase activity for cancer therapy
por: Mégnin-Chanet, Frédérique, et al.
Publicado: (2010)

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
por: Slade, Dea, et al.
Publicado: (2011)

Selective Down-Regulation of Nuclear Poly(ADP-Ribose) Glycohydrolase
por: Burns, David M., et al.
Publicado: (2009)

Lipoxygenases and Poly(ADP-Ribose) Polymerase in Amyloid Beta Cytotoxicity
por: Strosznajder, Joanna B., et al.
Publicado: (2011)

Reprogramming cellular events by poly(ADP-ribose)-binding proteins
por: Krietsch, Jana, et al.
Publicado: (2013)

Crystallographic and Biochemical Analysis of the Mouse Poly(ADP-Ribose) Glycohydrolase
por: Wang, Zhizhi, et al.
Publicado: (2014)

Analysis of Poly(ADP-Ribose) Polymerases in Arabidopsis Telomere Biology
por: Boltz, Kara A., et al.
Publicado: (2014)

The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis
por: García, Samuel, et al.
Publicado: (2015)

Overview on poly(ADP-ribose) immuno-biomedicine and future prospects
por: KANAI, Yoshiyuki
Publicado: (2016)

Poly (ADP-ribose) polymerase inhibitors in the management of ovarian cancer
por: Markman, Maurie
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_39le9s4d5qitqc6ve0fhnddesc