The role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness in vitro and in vivo

To date, only low pathogenic (LP) H5 and H7 avian influenza viruses (AIV) have been observed to naturally shift to a highly pathogenic (HP) phenotype after mutation of the monobasic hemagglutinin (HA) cleavage site (HACS) to polybasic motifs. The LPAIV monobasic HACS is activated by tissue-restricte...

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Detalles Bibliográficos
Autores principales: Gischke, Marcel, Bagato, Ola, Breithaupt, Angele, Scheibner, David, Blaurock, Claudia, Vallbracht, Melina, Karger, Axel, Crossley, Beate, Veits, Jutta, Böttcher-Friebertshäuser, Eva, Mettenleiter, Thomas C., Abdelwhab, Elsayed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872060/
https://www.ncbi.nlm.nih.gov/pubmed/33538209
http://dx.doi.org/10.1080/21505594.2021.1881344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872060/
https://www.ncbi.nlm.nih.gov/pubmed/33538209
http://dx.doi.org/10.1080/21505594.2021.1881344

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