Cargando…

The role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness in vitro and in vivo

To date, only low pathogenic (LP) H5 and H7 avian influenza viruses (AIV) have been observed to naturally shift to a highly pathogenic (HP) phenotype after mutation of the monobasic hemagglutinin (HA) cleavage site (HACS) to polybasic motifs. The LPAIV monobasic HACS is activated by tissue-restricte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gischke, Marcel, Bagato, Ola, Breithaupt, Angele, Scheibner, David, Blaurock, Claudia, Vallbracht, Melina, Karger, Axel, Crossley, Beate, Veits, Jutta, Böttcher-Friebertshäuser, Eva, Mettenleiter, Thomas C., Abdelwhab, Elsayed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872060/ https://www.ncbi.nlm.nih.gov/pubmed/33538209 http://dx.doi.org/10.1080/21505594.2021.1881344

Ejemplares similares

Non-basic amino acids in the hemagglutinin proteolytic cleavage site of a European H9N2 avian influenza virus modulate virulence in turkeys
por: Blaurock, Claudia, et al.
Publicado: (2020)

Insertion of Basic Amino Acids in the Hemagglutinin Cleavage Site of H4N2 Avian Influenza Virus (AIV)—Reduced Virus Fitness in Chickens is Restored by Reassortment with Highly Pathogenic H5N1 AIV
por: Gischke, Marcel, et al.
Publicado: (2020)

Variable impact of the hemagglutinin polybasic cleavage site on virulence and pathogenesis of avian influenza H7N7 virus in chickens, turkeys and ducks
por: Scheibner, David, et al.
Publicado: (2019)

Impact of Mutations in the Hemagglutinin of H10N7 Viruses Isolated from Seals on Virus Replication in Avian and Human Cells
por: Dittrich, Anne, et al.
Publicado: (2018)

Composition of the Hemagglutinin Polybasic Proteolytic Cleavage Motif Mediates Variable Virulence of H7N7 Avian Influenza Viruses
por: Abdelwhab, E. M., et al.
Publicado: (2016)

Highly Pathogenic H5N1 Influenza Viruses Carry Virulence Determinants beyond the Polybasic Hemagglutinin Cleavage Site
por: Bogs, Jessica, et al.
Publicado: (2010)

Virulence of three European highly pathogenic H7N1 and H7N7 avian influenza viruses in Pekin and Muscovy ducks
por: Scheibner, David, et al.
Publicado: (2019)

Genetic incompatibilities and reduced transmission in chickens may limit the evolution of reassortants between H9N2 and panzootic H5N8 clade 2.3.4.4 avian influenza virus showing high virulence for mammals
por: Mostafa, Ahmed, et al.
Publicado: (2020)

Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses
por: Scheibner, David, et al.
Publicado: (2023)

The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice
por: Blaurock, Claudia, et al.
Publicado: (2021)

Potential Biological and Climatic Factors That Influence the Incidence and Persistence of Highly Pathogenic H5N1 Avian Influenza Virus in Egypt
por: Salaheldin, Ahmed H., et al.
Publicado: (2018)

Avian influenza virus NS1: A small protein with diverse and versatile functions
por: Abdelwhab, E M, et al.
Publicado: (2013)

The Neuraminidase Stalk Deletion Serves as Major Virulence Determinant of H5N1 Highly Pathogenic Avian Influenza Viruses in Chicken
por: Stech, Olga, et al.
Publicado: (2015)

Multiple Introductions of Influenza A(H5N8) Virus into Poultry, Egypt, 2017
por: Salaheldin, Ahmed H., et al.
Publicado: (2018)

Influence of N-glycosylation on Expression and Function of Pseudorabies Virus Glycoprotein gB
por: Vallbracht, Melina, et al.
Publicado: (2021)

Genetic changes that accompanied shifts of low pathogenic avian influenza viruses toward higher pathogenicity in poultry
por: Abdelwhab, El-Sayed M, et al.
Publicado: (2013)

Light Sheet Microscopy-Assisted 3D Analysis of SARS-CoV-2 Infection in the Respiratory Tract of the Ferret Model
por: Zaeck, Luca M., et al.
Publicado: (2021)

Immunization with Plant-Derived Multimeric H5 Hemagglutinins Protect Chicken against Highly Pathogenic Avian Influenza Virus H5N1
por: Phan, Hoang Trong, et al.
Publicado: (2020)

Isolation and genetic characterization of a novel 2.2.1.2a H5N1 virus from a vaccinated meat-turkeys flock in Egypt
por: Salaheldin, Ahmed H., et al.
Publicado: (2017)

Monoclonal antibodies targeting the synthetic peptide corresponding to the polybasic cleavage site on H5N1 influenza hemagglutinin
por: Tsai, Henry J, et al.
Publicado: (2012)

A viral race for primacy: co-infection of a natural pair of low and highly pathogenic H7N7 avian influenza viruses in chickens and embryonated chicken eggs
por: Graaf, Annika, et al.
Publicado: (2018)

A Semiquantitative Scoring System for Histopathological and Immunohistochemical Assessment of Lesions and Tissue Tropism in Avian Influenza
por: Landmann, Maria, et al.
Publicado: (2021)

The N-Terminal, Polybasic Region Is Critical for Prion Protein Neuroprotective Activity
por: Turnbaugh, Jessie A., et al.
Publicado: (2011)

Genetic Predisposition To Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin
por: Nao, Naganori, et al.
Publicado: (2017)

Chimeric Newcastle Disease Virus Protects Chickens against Avian Influenza in the Presence of Maternally Derived NDV Immunity
por: Steglich, Constanze, et al.
Publicado: (2013)

Membrane-Bound Configuration and Lipid Perturbing Effects of Hemagglutinin Subunit 2 N-Terminus Investigated by Computer Simulations
por: Michalski, Michal, et al.
Publicado: (2022)

Zoonotic Animal Influenza Virus and Potential Mixing Vessel Hosts
por: Abdelwhab, Elsayed M., et al.
Publicado: (2023)

Pathogenicity of Highly Pathogenic Avian Influenza Virus (H5N1) in Adult Mute Swans
por: Kalthoff, Donata, et al.
Publicado: (2008)

Experimental Infection and Natural Contact Exposure of Dogs with Avian Influenza Virus (H5N1)
por: Giese, Matthias, et al.
Publicado: (2008)

The protease-sensitive N-terminal polybasic region of prion protein modulates its conversion to the pathogenic prion conformer
por: Zhang, Xiangyi, et al.
Publicado: (2021)

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
por: Wu, Bei, et al.
Publicado: (2017)

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview
por: Mostafa, Ahmed, et al.
Publicado: (2018)

Solid Phase Formylation of N-Terminus Peptides
por: Tornesello, Anna Lucia, et al.
Publicado: (2016)

Anmerkungen zum Terminus „Drainage“
por: Böttcher, Arne, et al.
Publicado: (2022)

Streptophyte phytochromes exhibit an N-terminus of cyanobacterial origin and a C-terminus of proteobacterial origin
por: Buchberger, Thorsten, et al.
Publicado: (2015)

Albumin Fusion at the N-Terminus or C-Terminus of HM-3 Leads to Improved Pharmacokinetics and Bioactivities
por: Li, Ting, et al.
Publicado: (2021)

Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic
por: Blaurock, Claudia, et al.
Publicado: (2022)

The N-terminus of mature human frataxin is intrinsically unfolded
por: Prischi, Filippo, et al.
Publicado: (2009)

The N terminus of α-synuclein dictates fibril formation
por: McGlinchey, Ryan P., et al.
Publicado: (2021)

Copper-mediated peptide arylation selective for the N-terminus
por: Miller, Mary K., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6tko2b2of2r3ct69n50brskvs2