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Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients
The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cell...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872097/ https://www.ncbi.nlm.nih.gov/pubmed/33643691 http://dx.doi.org/10.1080/2162402X.2021.1873585 |
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author | de Jonge, Kaat Tillé, Laure Lourenco, Joao Maby-El Hajjami, Hélène Nassiri, Sina Racle, Julien Gfeller, David Delorenzi, Mauro Verdeil, Grégory Baumgaertner, Petra Speiser, Daniel E. |
author_facet | de Jonge, Kaat Tillé, Laure Lourenco, Joao Maby-El Hajjami, Hélène Nassiri, Sina Racle, Julien Gfeller, David Delorenzi, Mauro Verdeil, Grégory Baumgaertner, Petra Speiser, Daniel E. |
author_sort | de Jonge, Kaat |
collection | PubMed |
description | The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets. |
format | Online Article Text |
id | pubmed-7872097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-78720972021-02-26 Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients de Jonge, Kaat Tillé, Laure Lourenco, Joao Maby-El Hajjami, Hélène Nassiri, Sina Racle, Julien Gfeller, David Delorenzi, Mauro Verdeil, Grégory Baumgaertner, Petra Speiser, Daniel E. Oncoimmunology Original Research The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets. Taylor & Francis 2021-02-02 /pmc/articles/PMC7872097/ /pubmed/33643691 http://dx.doi.org/10.1080/2162402X.2021.1873585 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research de Jonge, Kaat Tillé, Laure Lourenco, Joao Maby-El Hajjami, Hélène Nassiri, Sina Racle, Julien Gfeller, David Delorenzi, Mauro Verdeil, Grégory Baumgaertner, Petra Speiser, Daniel E. Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients |
title | Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients |
title_full | Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients |
title_fullStr | Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients |
title_full_unstemmed | Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients |
title_short | Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients |
title_sort | inflammatory b cells correlate with failure to checkpoint blockade in melanoma patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872097/ https://www.ncbi.nlm.nih.gov/pubmed/33643691 http://dx.doi.org/10.1080/2162402X.2021.1873585 |
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