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Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients

The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cell...

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Autores principales: de Jonge, Kaat, Tillé, Laure, Lourenco, Joao, Maby-El Hajjami, Hélène, Nassiri, Sina, Racle, Julien, Gfeller, David, Delorenzi, Mauro, Verdeil, Grégory, Baumgaertner, Petra, Speiser, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872097/
https://www.ncbi.nlm.nih.gov/pubmed/33643691
http://dx.doi.org/10.1080/2162402X.2021.1873585
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author de Jonge, Kaat
Tillé, Laure
Lourenco, Joao
Maby-El Hajjami, Hélène
Nassiri, Sina
Racle, Julien
Gfeller, David
Delorenzi, Mauro
Verdeil, Grégory
Baumgaertner, Petra
Speiser, Daniel E.
author_facet de Jonge, Kaat
Tillé, Laure
Lourenco, Joao
Maby-El Hajjami, Hélène
Nassiri, Sina
Racle, Julien
Gfeller, David
Delorenzi, Mauro
Verdeil, Grégory
Baumgaertner, Petra
Speiser, Daniel E.
author_sort de Jonge, Kaat
collection PubMed
description The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets.
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spelling pubmed-78720972021-02-26 Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients de Jonge, Kaat Tillé, Laure Lourenco, Joao Maby-El Hajjami, Hélène Nassiri, Sina Racle, Julien Gfeller, David Delorenzi, Mauro Verdeil, Grégory Baumgaertner, Petra Speiser, Daniel E. Oncoimmunology Original Research The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets. Taylor & Francis 2021-02-02 /pmc/articles/PMC7872097/ /pubmed/33643691 http://dx.doi.org/10.1080/2162402X.2021.1873585 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
de Jonge, Kaat
Tillé, Laure
Lourenco, Joao
Maby-El Hajjami, Hélène
Nassiri, Sina
Racle, Julien
Gfeller, David
Delorenzi, Mauro
Verdeil, Grégory
Baumgaertner, Petra
Speiser, Daniel E.
Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients
title Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients
title_full Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients
title_fullStr Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients
title_full_unstemmed Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients
title_short Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients
title_sort inflammatory b cells correlate with failure to checkpoint blockade in melanoma patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872097/
https://www.ncbi.nlm.nih.gov/pubmed/33643691
http://dx.doi.org/10.1080/2162402X.2021.1873585
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