Targeting CTP Synthetase 1 to Restore Interferon Induction and Impede Nucleotide Synthesis in SARS-CoV-2 Infection

The newly emerged SARS-CoV-2 caused a global pandemic with astonishing mortality and morbidity. The mechanisms underpinning its highly infectious nature remain poorly understood. We report here that SARS-CoV-2 exploits cellular CTP synthetase 1 (CTPS1) to promote CTP synthesis and suppress interfero...

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Detalles Bibliográficos
Autores principales: Rao, Youliang, Wang, Ting-Yu, Qin, Chao, Espinosa, Bianca, Liu, Qizhi, Ekanayake, Arunika, Zhao, Jun, Savas, Ali Can, Zhang, Shu, Zarinfar, Mehrnaz, Liu, Yongzhen, Zhu, Wenjie, Graham, Nicholas, Jiang, Taijiao, Zhang, Chao, Feng, Pinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872357/
https://www.ncbi.nlm.nih.gov/pubmed/33564769
http://dx.doi.org/10.1101/2021.02.05.429959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872357/
https://www.ncbi.nlm.nih.gov/pubmed/33564769
http://dx.doi.org/10.1101/2021.02.05.429959

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