Mining Natural Products for Macrocycles to Drug Difficult Targets

[Image: see text] Lead generation for difficult-to-drug targets that have large, featureless, and highly lipophilic or highly polar and/or flexible binding sites is highly challenging. Here, we describe how cores of macrocyclic natural products can serve as a high-quality in silico screening library...

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Detalles Bibliográficos
Autores principales: Begnini, Fabio, Poongavanam, Vasanthanathan, Over, Björn, Castaldo, Marie, Geschwindner, Stefan, Johansson, Patrik, Tyagi, Mohit, Tyrchan, Christian, Wissler, Lisa, Sjö, Peter, Schiesser, Stefan, Kihlberg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872424/
https://www.ncbi.nlm.nih.gov/pubmed/33337880
http://dx.doi.org/10.1021/acs.jmedchem.0c01569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872424/
https://www.ncbi.nlm.nih.gov/pubmed/33337880
http://dx.doi.org/10.1021/acs.jmedchem.0c01569

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