Cargando…
Mining Natural Products for Macrocycles to Drug Difficult Targets
[Image: see text] Lead generation for difficult-to-drug targets that have large, featureless, and highly lipophilic or highly polar and/or flexible binding sites is highly challenging. Here, we describe how cores of macrocyclic natural products can serve as a high-quality in silico screening library...
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872424/ https://www.ncbi.nlm.nih.gov/pubmed/33337880 http://dx.doi.org/10.1021/acs.jmedchem.0c01569 |