Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

Sequencing of cancer genomes has identified recurrent somatic mutations in histones, termed oncohistones, which are frequently poorly understood. Previously we showed that fission yeast expressing only the H3.3G34R mutant identified in aggressive pediatric glioma had reduced H3K36 trimethylation and...

Descripción completa

Detalles Bibliográficos
Autores principales: Lowe, Brandon R, Yadav, Rajesh K, Henry, Ryan A, Schreiner, Patrick, Matsuda, Atsushi, Fernandez, Alfonso G, Finkelstein, David, Campbell, Margaret, Kallappagoudar, Satish, Jablonowski, Carolyn M, Andrews, Andrew J, Hiraoka, Yasushi, Partridge, Janet F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872514/
https://www.ncbi.nlm.nih.gov/pubmed/33522486
http://dx.doi.org/10.7554/eLife.65369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872514/
https://www.ncbi.nlm.nih.gov/pubmed/33522486
http://dx.doi.org/10.7554/eLife.65369

Ejemplares similares