Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure and function, as well as the pathogenic mechanisms, remain unclear. We determ...

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Detalles Bibliográficos
Autores principales: Nguyen, Giang Thi Tuyet, Sutinen, Aleksi, Raasakka, Arne, Muruganandam, Gopinath, Loris, Remy, Kursula, Petri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873046/
https://www.ncbi.nlm.nih.gov/pubmed/33585569
http://dx.doi.org/10.3389/fmolb.2020.631232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873046/
https://www.ncbi.nlm.nih.gov/pubmed/33585569
http://dx.doi.org/10.3389/fmolb.2020.631232

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