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Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure and function, as well as the pathogenic mechanisms, remain unclear. We determ...

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Detalles Bibliográficos
Autores principales:	Nguyen, Giang Thi Tuyet, Sutinen, Aleksi, Raasakka, Arne, Muruganandam, Gopinath, Loris, Remy, Kursula, Petri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873046/ https://www.ncbi.nlm.nih.gov/pubmed/33585569 http://dx.doi.org/10.3389/fmolb.2020.631232

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