Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on serine synthesis are...

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Detalles Bibliográficos
Autores principales: Jiang, Lingyan, Wang, Peisheng, Song, Xiaorui, Zhang, Huan, Ma, Shuangshuang, Wang, Jingting, Li, Wanwu, Lv, Runxia, Liu, Xiaoqian, Ma, Shuai, Yan, Jiaqi, Zhou, Haiyan, Huang, Di, Cheng, Zhihui, Yang, Chen, Feng, Lu, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873081/
https://www.ncbi.nlm.nih.gov/pubmed/33563986
http://dx.doi.org/10.1038/s41467-021-21186-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873081/
https://www.ncbi.nlm.nih.gov/pubmed/33563986
http://dx.doi.org/10.1038/s41467-021-21186-4

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