Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7

Cell surface heparan sulfate proteoglycan (HSPG)-mediated endocytosis results in poor yields of recombinant human bone morphogenetic proteins (rhBMPs) from CHO cell cultures. Upon incubation of rhBMP-2 and rhBMP-7 with CHO cells at 37 °C, both rhBMP-2 and rhBMP-7 bound to the cell surface HSPGs in C...

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Detalles Bibliográficos
Autores principales: Kim, Mi Gyeom, Kim, Che Lin, Kim, Young Sik, Jang, Ju Woong, Lee, Gyun Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873082/
https://www.ncbi.nlm.nih.gov/pubmed/33564092
http://dx.doi.org/10.1038/s41598-021-82955-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873082/
https://www.ncbi.nlm.nih.gov/pubmed/33564092
http://dx.doi.org/10.1038/s41598-021-82955-1

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