The metalloproteinase ADAM10 requires its activity to sustain surface expression

The metalloproteinase ADAM10 critically contributes to development, inflammation, and cancer and can be controlled by endogenous or synthetic inhibitors. Here, we demonstrate for the first time that loss of proteolytic activity of ADAM10 by either inhibition or loss of function mutations induces rem...

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Detalles Bibliográficos
Autores principales: Seifert, Anke, Düsterhöft, Stefan, Wozniak, Justyna, Koo, Chek Z., Tomlinson, Michael G., Nuti, Elisa, Rossello, Armando, Cuffaro, Doretta, Yildiz, Daniela, Ludwig, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873107/
https://www.ncbi.nlm.nih.gov/pubmed/32372373
http://dx.doi.org/10.1007/s00018-020-03507-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873107/
https://www.ncbi.nlm.nih.gov/pubmed/32372373
http://dx.doi.org/10.1007/s00018-020-03507-w

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