Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

The HIV-1 envelope glycoprotein trimer is poorly immunogenic because it is covered by a dense glycan shield. As a result, recombinant Env glycoproteins generally elicit inadequate antibody levels that neutralize clinically relevant, neutralization-resistant (Tier-2) HIV-1 strains. Multivalent antige...

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Detalles Bibliográficos
Autores principales: Brouwer, Philip J. M., Antanasijevic, Aleksandar, de Gast, Marlon, Allen, Joel D., Bijl, Tom P. L., Yasmeen, Anila, Ravichandran, Rashmi, Burger, Judith A., Ozorowski, Gabriel, Torres, Jonathan L., LaBranche, Celia, Montefiori, David C., Ringe, Rajesh P., van Gils, Marit J., Moore, John P., Klasse, Per Johan, Crispin, Max, King, Neil P., Ward, Andrew B., Sanders, Rogier W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873233/
https://www.ncbi.nlm.nih.gov/pubmed/33563983
http://dx.doi.org/10.1038/s41541-021-00285-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873233/
https://www.ncbi.nlm.nih.gov/pubmed/33563983
http://dx.doi.org/10.1038/s41541-021-00285-9

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