Astrocytic expression of the Alzheimer’s disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models

ApoEε4 is a major genetic risk factor for Alzheimer’s disease (AD), a disease hallmarked by extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). The presence of the ApoEε4 allele is associated with increased Aβ deposition and a role for ApoEε4 in the potentiation...

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Detalles Bibliográficos
Autores principales: Jablonski, Angela Marie, Warren, Lee, Usenovic, Marija, Zhou, Heather, Sugam, Jonathan, Parmentier-Batteur, Sophie, Voleti, Bhavya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873246/
https://www.ncbi.nlm.nih.gov/pubmed/33564035
http://dx.doi.org/10.1038/s41598-021-82901-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873246/
https://www.ncbi.nlm.nih.gov/pubmed/33564035
http://dx.doi.org/10.1038/s41598-021-82901-1

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