Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

Histone phosphorylation is a ubiquitous post-translational modification that allows eukaryotic cells to rapidly respond to environmental stimuli. Despite correlative evidence linking histone phosphorylation to changes in gene expression, establishing the causal role of this key epigenomic modificati...

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Detalles Bibliográficos
Autores principales: Li, Jing, Mahata, Barun, Escobar, Mario, Goell, Jacob, Wang, Kaiyuan, Khemka, Pranav, Hilton, Isaac B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873277/
https://www.ncbi.nlm.nih.gov/pubmed/33563994
http://dx.doi.org/10.1038/s41467-021-21188-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873277/
https://www.ncbi.nlm.nih.gov/pubmed/33563994
http://dx.doi.org/10.1038/s41467-021-21188-2

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