Cargando…

Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes

Cynandione A, an acetophenone isolated from Cynanchum Wilfordii Radix, exhibits antineuropathic pain effect. This study further explored the target molecule and signaling mechanisms underlying cynandione-A-induced antineuropathic pain. Intrathecal injection of cynandione A significantly attenuated m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Qiao-Qiao, Yin, Min, Wang, Zi-Ying, Liu, Hao, Ao, Jun-Ping, Wang, Yong-Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873367/ https://www.ncbi.nlm.nih.gov/pubmed/33584292 http://dx.doi.org/10.3389/fphar.2020.614450

Ejemplares similares

Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs
por: Ho, Thao N.T., et al.
Publicado: (2021)

Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson’s Disease Rats
por: Zhou, Li, et al.
Publicado: (2021)

Cytisine Exerts an Anti-Epileptic Effect via α7nAChRs in a Rat Model of Temporal Lobe Epilepsy
por: Zheng, Jing-jun, et al.
Publicado: (2021)

Sulfonium Ligands of the α7 nAChR
por: Horenstein, Nicole A., et al.
Publicado: (2021)

Vagal α7nAChR signaling regulates α7nAChR(+)Sca1(+) cells during lung injury repair
por: Chen, Xiaoyan, et al.
Publicado: (2020)

Farnesyl Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking
por: Chen, Tingting, et al.
Publicado: (2020)

The Regulation Effect of α7nAChRs and M1AChRs on Inflammation and Immunity in Sepsis
por: Hu, Song, et al.
Publicado: (2021)

Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR
por: El Hamdaoui, Yamina, et al.
Publicado: (2019)

α-Conotoxin as Potential to α7-nAChR Recombinant Expressed in Escherichia coli
por: Liu, Yanli, et al.
Publicado: (2020)

GTS-21 Promotes α7 nAChR to Alleviate Intestinal Ischemia-Reperfusion-Induced Apoptosis and Inflammation of Enterocytes
por: Wang, Haisong, et al.
Publicado: (2020)

E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR α7 Receptor: Role of nAChR α7 in ACE2 Covid-19 receptor regulation
por: Wang, Qixin, et al.
Publicado: (2020)

Role of α7nAChR-NMDAR in sevoflurane-induced memory deficits in the developing rat hippocampus
por: Tang, XiaoHong, et al.
Publicado: (2018)

Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea
por: Vyas, Pankhuri, et al.
Publicado: (2020)

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
por: Lin, Bo, et al.
Publicado: (2016)

Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages
por: Liu, Etta Y.L., et al.
Publicado: (2020)

Semisynthetic Analogues of Toxiferine I and Their Pharmacological Properties at α7 nAChRs, Muscle-Type nAChRs, and the Allosteric Binding Site of Muscarinic M(2) Receptors
por: Zlotos, Darius P., et al.
Publicado: (2014)

α7nAchR/NMDAR coupling affects NMDAR function and object recognition
por: Li, Shupeng, et al.
Publicado: (2013)

In silico studies of ASEM analogues targeting α7-nAChR and experimental verification
por: Zhou, Yang, et al.
Publicado: (2021)

Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization
por: Bondarenko, Vasyl, et al.
Publicado: (2023)

Electroacupuncture Alleviates Inflammation of Dry Eye Diseases by Regulating the α7nAChR/NF-κB Signaling Pathway
por: Ding, Ning, et al.
Publicado: (2021)

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation
por: Wang, Qixin, et al.
Publicado: (2020)

The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials
por: Yang, Taoyi, et al.
Publicado: (2017)

Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders
por: Kalkman, Hans O., et al.
Publicado: (2016)

Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis
por: Liu, Yuan, et al.
Publicado: (2021)

Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients
por: Courties, Alice, et al.
Publicado: (2021)

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity
por: Dutertre, Sébastien, et al.
Publicado: (2007)

From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR
por: Pan, Si, et al.
Publicado: (2021)

The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site
por: Gulsevin, Alican, et al.
Publicado: (2021)

Tumor suppressor menin is required for subunit-specific nAChR α5 transcription and nAChR-dependent presynaptic facilitation in cultured mouse hippocampal neurons
por: Getz, Angela M., et al.
Publicado: (2017)

Nicotine regulates autophagy of human periodontal ligament cells through α7 nAchR that promotes secretion of inflammatory factors IL-1β and IL-8
por: Du, Yang, et al.
Publicado: (2021)

Regulation of RIC-3 and of nAChR expression
por: Ben-David, Yael, et al.
Publicado: (2016)

Total synthesis of the natural (−)-205B alkaloid and its activity toward α7 nAChRs
por: Mazeh, Sara, et al.
Publicado: (2022)

Nicotine suppresses apoptosis by regulating α7nAChR/Prx1 axis in oral precancerous lesions
por: Wang, Chunxiao, et al.
Publicado: (2017)

Blockade of Neuronal α7-nAChR by α-Conotoxin ImI Explained by Computational Scanning and Energy Calculations
por: Yu, Rilei, et al.
Publicado: (2011)

Spinal microglial β‐endorphin signaling mediates IL‐10 and exenatide‐induced inhibition of synaptic plasticity in neuropathic pain
por: Ma, Le, et al.
Publicado: (2021)

Vagus Nerve through α7 nAChR Modulates Lung Infection and Inflammation: Models, Cells, and Signals
por: Wu, Haiya, et al.
Publicado: (2014)

Eliciting α7‐nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling
por: Lin, Zhong‐Hao, et al.
Publicado: (2019)

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux
por: Farré-Alins, Víctor, et al.
Publicado: (2020)

Disrupting the α7nAChR–NR2A protein complex exerts antidepressant-like effects
por: Jiang, Anlong, et al.
Publicado: (2021)

Natural Polyhydroxy Flavonoids, Curcuminoids, and Synthetic Curcumin Analogs as α7 nAChRs Positive Allosteric Modulators
por: Ximenis, Marta, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gkb6li6o8csk9q6kk0adnpcfg6