Inactivation of N-Acetylglucosaminyltransferase I and α1,3-Fucosyltransferase Genes in Nicotiana tabacum BY-2 Cells Results in Glycoproteins With Highly Homogeneous, High-Mannose N-Glycans

Nicotiana tabacum Bright Yellow-2 (BY-2) suspension cells are among the most commonly used plant cell lines for producing biopharmaceutical glycoproteins. Recombinant glycoproteins are usually produced with a mix of high-mannose and complex N-glycans. However, N-glycan heterogeneity is a concern for...

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Detalles Bibliográficos
Autores principales: Herman, Xavier, Far, Johann, Courtoy, Adeline, Bouhon, Laurent, Quinton, Loïc, De Pauw, Edwin, Chaumont, François, Navarre, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Plant Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873608/
https://www.ncbi.nlm.nih.gov/pubmed/33584780
http://dx.doi.org/10.3389/fpls.2021.634023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873608/
https://www.ncbi.nlm.nih.gov/pubmed/33584780
http://dx.doi.org/10.3389/fpls.2021.634023

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