Serum-Based KRAS(G12/G13) Mutation Detection Using Droplet Digital PCR: Clinical Implications and Limitations in Colorectal Adenocarcinoma With Tumor Heterogeneity

BACKGROUND: Cell-free DNA (cfDNA) has arisen as an alternative target for evaluating somatic mutations in cancer. KRAS mutation status is critical for targeted therapy in colorectal adenocarcinoma (CRAC). We evaluated KRAS(G12/G13) mutations in cfDNA extracted from serum and compared the results wit...

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Detalles Bibliográficos
Autores principales: Kim, Ju Seok, Bae, Go Eun, Kim, Seok-Hwan, Choi, Min Kyung, Yeo, Min-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873888/
https://www.ncbi.nlm.nih.gov/pubmed/33585224
http://dx.doi.org/10.3389/fonc.2020.604772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873888/
https://www.ncbi.nlm.nih.gov/pubmed/33585224
http://dx.doi.org/10.3389/fonc.2020.604772

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