P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3(*)Leiden Mice via Systemic Inhibition of Regulatory T Cells

Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficienc...

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Detalles Bibliográficos
Autores principales: de Jong, Alwin, de Jong, Rob C. M., Peters, Erna A., Arens, Ramon, Jukema, J. Wouter, de Vries, Margreet R., Quax, Paul H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874080/
https://www.ncbi.nlm.nih.gov/pubmed/33585580
http://dx.doi.org/10.3389/fcvm.2020.604821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874080/
https://www.ncbi.nlm.nih.gov/pubmed/33585580
http://dx.doi.org/10.3389/fcvm.2020.604821

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