Cargando…

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3(*)Leiden Mice via Systemic Inhibition of Regulatory T Cells

Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficienc...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Jong, Alwin, de Jong, Rob C. M., Peters, Erna A., Arens, Ramon, Jukema, J. Wouter, de Vries, Margreet R., Quax, Paul H. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874080/ https://www.ncbi.nlm.nih.gov/pubmed/33585580 http://dx.doi.org/10.3389/fcvm.2020.604821

Ejemplares similares

The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice
por: Hoving, Lisa R., et al.
Publicado: (2018)

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development
por: de Jong, Rob C. M., et al.
Publicado: (2017)

P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy
por: Jia, Yu-Li, et al.
Publicado: (2016)

Prolonged Hyperoxygenation Treatment Improves Vein Graft Patency and Decreases Macrophage Content in Atherosclerotic Lesions in ApoE3*Leiden Mice
por: Parma, Laura, et al.
Publicado: (2020)

bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice
por: Parma, Laura, et al.
Publicado: (2020)

The Role of Immunomodulation in Vein Graft Remodeling and Failure
por: Baganha, Fabiana, et al.
Publicado: (2020)

The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP
por: Chérasse, Yoan, et al.
Publicado: (2007)

Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization
por: Baganha, Fabiana, et al.
Publicado: (2021)

CD8+ T Cells Protect During Vein Graft Disease Development
por: Simons, Karin H., et al.
Publicado: (2019)

Acetyltransferase p300/CBP Associated Factor (PCAF) Regulates Crosstalk-Dependent Acetylation of Histone H3 by Distal Site Recognition
por: Kornacki, James R., et al.
Publicado: (2014)

Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol
por: Kühnast, Susan, et al.
Publicado: (2013)

Continuous Light Does Not Affect Atherosclerosis in APOE*3-Leiden.CETP Mice
por: Schilperoort, Maaike, et al.
Publicado: (2020)

Disruption of circadian rhythm by alternating light‐dark cycles aggravates atherosclerosis development in APOE*3‐Leiden.CETP mice
por: Schilperoort, Maaike, et al.
Publicado: (2019)

IRF3 and IRF7 mediate neovascularization via inflammatory cytokines
por: Simons, Karin H., et al.
Publicado: (2019)

Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice
por: Creighton, Samantha D., et al.
Publicado: (2022)

P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer
por: Cheng, Yin‐Wei, et al.
Publicado: (2021)

Dose Effects of Ammonium Perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP Mice
por: Pouwer, Marianne G, et al.
Publicado: (2019)

The APOE(∗)3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis
por: Pouwer, Marianne G., et al.
Publicado: (2019)

Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours
por: Özdağ, H, et al.
Publicado: (2002)

Interfering in the ALK1 Pathway Results in Macrophage-Driven Outward Remodeling of Murine Vein Grafts
por: de Jong, Alwin, et al.
Publicado: (2022)

Metformin Induces Apoptosis in Human Pancreatic Cancer (PC) Cells Accompanied by Changes in the Levels of Histone Acetyltransferases (Particularly, p300/CBP-Associated Factor (PCAF) Protein Levels)
por: Szymczak-Pajor, Izabela, et al.
Publicado: (2023)

The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice
por: Landlinger, Christine, et al.
Publicado: (2017)

Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents
por: Chen, Qingjuan, et al.
Publicado: (2022)

Visualization of Murine Vascular Remodeling and Blood Flow Dynamics by Ultra-High-Frequency Ultrasound Imaging
por: Sier, Vincent Q., et al.
Publicado: (2022)

Akkermansia muciniphila Exerts Lipid‐Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3‐Leiden.CETP Mice
por: Katiraei, Saeed, et al.
Publicado: (2019)

Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response
por: de Jong, Rob C. M., et al.
Publicado: (2018)

Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response
por: Pluijmert, Niek J., et al.
Publicado: (2020)

Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post‐ischaemic inflammatory response
por: Pluijmert, Niek J., et al.
Publicado: (2021)

MZF1 (Myeloid Zinc Finger 1) activates transcriptional activity of p53 and suppresses breast cancer cell proliferation via acetyltransferase PCAF (P300/CBP associated factor)
por: Li, Bowen, et al.
Publicado: (2022)

Protein Lysine Acetylation by p300/CBP
por: Dancy, Beverley M., et al.
Publicado: (2015)

Coactivators p300 and PCAF physically and functionally interact with the foamy viral trans-activator
por: Bannert, Helmut, et al.
Publicado: (2004)

Atorvastatin Attenuates Diet-Induced Non-Alcoholic Steatohepatitis in APOE*3-Leiden Mice by Reducing Hepatic Inflammation
por: Inia, José A., et al.
Publicado: (2023)

The prebiotic inulin modulates gut microbiota but does not ameliorate atherosclerosis in hypercholesterolemic APOE*3-Leiden.CETP mice
por: Hoving, Lisa R., et al.
Publicado: (2018)

Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice
por: van Eenige, Robin, et al.
Publicado: (2021)

Curcumin, COX-2, and Protein p300/CBP
por: Jung, Ki Tae, et al.
Publicado: (2014)

Dimeric structure of p300/CBP associated factor
por: Shi, Shasha, et al.
Publicado: (2014)

Correction to Protein Lysine Acetylation by p300/CBP
por: Dancy, Beverley M., et al.
Publicado: (2016)

The Effect of PPE-Induced Emphysema and Chronic LPS-Induced Pulmonary Inflammation on Atherosclerosis Development in APOE*3-LEIDEN Mice
por: Khedoe, P. Padmini S. J, et al.
Publicado: (2013)

Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans
por: van Keulen, Danielle, et al.
Publicado: (2019)

Mild Exercise Does Not Prevent Atherosclerosis in APOE*3‐Leiden.CETP Mice or Improve Lipoprotein Profile of Men with Obesity
por: In het Panhuis, Wietse, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2k7t2lv6gtnbv55gdklvdas02p