Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure. A key signaling molecule involved in cardiac hypertrophy is protein kina...

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Detalles Bibliográficos
Autores principales: Pohjolainen, Lotta, Easton, Julia, Solanki, Reesha, Ruskoaho, Heikki, Talman, Virpi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874215/
https://www.ncbi.nlm.nih.gov/pubmed/33584253
http://dx.doi.org/10.3389/fphar.2020.553852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874215/
https://www.ncbi.nlm.nih.gov/pubmed/33584253
http://dx.doi.org/10.3389/fphar.2020.553852

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