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α-ketoglutarate promotes the specialization of primordial germ cell-like cells through regulating epigenetic reprogramming

There is growing evidence that cellular metabolism can directly participate in epigenetic dynamics and consequently modulate gene expression. However, the role of metabolites in activating the key gene regulatory network for specialization of germ cell lineage remains largely unknown. Here, we ident...

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Detalles Bibliográficos
Autores principales: Xing, Ming, Wang, Na, Zeng, Hanyi, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874270/
https://www.ncbi.nlm.nih.gov/pubmed/32994387
http://dx.doi.org/10.7555/JBR.34.20190160