Cargando…

MED19 alters AR occupancy and gene expression in prostate cancer cells, driving MAOA expression and growth under low androgen

Androgen deprivation therapy (ADT) is a mainstay of prostate cancer treatment, given the dependence of prostate cells on androgen and the androgen receptor (AR). However, tumors become ADT-resistant, and there is a need to understand the mechanism. One possible mechanism is the upregulation of AR co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weber, Hannah, Ruoff, Rachel, Garabedian, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875385/ https://www.ncbi.nlm.nih.gov/pubmed/33513133 http://dx.doi.org/10.1371/journal.pgen.1008540

Ejemplares similares

MED19 encodes two unique protein isoforms that confer prostate cancer growth under low androgen through distinct gene expression programs
por: Ruoff, Rachel, et al.
Publicado: (2023)

Racial Differences in Androgen Receptor (AR) and AR Splice Variants (AR-SVs) Expression in Treatment-Naïve Androgen-Dependent Prostate Cancer
por: Khan, Farhan, et al.
Publicado: (2023)

MAOA EXPRESSION PREDICTS VULNERABILITY FOR ALCOHOL USE
por: Cervera-Juanes, Rita, et al.
Publicado: (2015)

Therapeutic targeting of the androgen receptor (AR) and AR variants in prostate cancer
por: Narayanan, Ramesh
Publicado: (2020)

Phosphorylation of the Androgen Receptor by PIM1 in Hormone Refractory Prostate Cancer
por: Ha, Susan, et al.
Publicado: (2012)

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression
por: Márquez, C, et al.
Publicado: (2013)

Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases
por: Kallio, Heini M. L., et al.
Publicado: (2018)

Feirer 40 år med Internett
Publicado: (2009)

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression
por: Li, Yingming, et al.
Publicado: (2012)

Immunohistochemical Expression of Androgen Receptors (AR) in Various Breast Cancer Subtypes
por: Ismael, Nour El Hoda S., et al.
Publicado: (2019)

Drivers of AR indifferent anti-androgen resistance in prostate cancer cells
por: Handle, Florian, et al.
Publicado: (2019)

MAOA Influences the Trajectory of Attentional Development
por: Lundwall, Rebecca A., et al.
Publicado: (2016)

Detection of androgen receptor (AR) and AR-V7 in small cell prostate carcinoma: Diagnostic and therapeutic implications
por: Zhao, Pei, et al.
Publicado: (2019)

Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction
por: Xu, Defeng, et al.
Publicado: (2017)

Dual inhibition of survivin and MAOA synergistically impairs growth of PTEN-negative prostate cancer
por: Xu, S, et al.
Publicado: (2015)

Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells
por: Chen, Congcong, et al.
Publicado: (2016)

Destroying the androgen receptor (AR)-potential strategy to treat advanced prostate cancer
por: Narayanan, Ramesh, et al.
Publicado: (2017)

Androgen Receptor-Mediated Growth Suppression of HPr-1AR and PC3-Lenti-AR Prostate Epithelial Cells
por: Kim, Young-Chae, et al.
Publicado: (2015)

MAOA haplotypes associated with thrombocyte-MAO activity
por: Jansson, Mårten, et al.
Publicado: (2005)

Plasticity of Functional MAOA Gene Methylation in Acrophobia
por: Schiele, Miriam A, et al.
Publicado: (2018)

Retraction “Methylation of the MAOA promoter is associated with schizophrenia”
por: Yang, Hao, et al.
Publicado: (2020)

Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
por: Claessens, Frank, et al.
Publicado: (2008)

Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence
por: Dahl, Haley C., et al.
Publicado: (2020)

Co-expression and clinical utility of AR-FL and AR splice variants AR-V3, AR-V7 and AR-V9 in prostate cancer
por: Wüstmann, Neele, et al.
Publicado: (2023)

Stilbene Induced Inhibition of Androgen Receptor Dimerization: Implications for AR and ARΔLBD-Signalling in Human Prostate Cancer Cells
por: Streicher, Wolfgang, et al.
Publicado: (2014)

Antiandrogen-Equipped Histone Deacetylase Inhibitors Selectively Inhibit Androgen Receptor (AR) and AR-Splice Variant (AR-SV) in Castration-Resistant Prostate Cancer (CRPC)
por: Chandrasekaran, Balaji, et al.
Publicado: (2023)

Expression of Androgen Receptor Variant 7 (AR-V7) in Circulated Tumor Cells and Correlation with Drug Resistance of Prostate Cancer Cells
por: Wang, Shuaibin, et al.
Publicado: (2018)

Correction: Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells
por: Chen, Congcong, et al.
Publicado: (2019)

Immune Modulation in Prostate Cancer Patients Treated with Androgen Receptor (AR)-Targeted Therapy
por: Conteduca, Vincenza, et al.
Publicado: (2020)

Nonmalignant AR-positive prostate epithelial cells and cancer cells respond differently to androgen
por: Kukkonen, Konsta, et al.
Publicado: (2022)

MAOA rs1137070 and heroin addiction interactively alter gray matter volume of the salience network
por: Sun, Yan, et al.
Publicado: (2017)

Early upregulation of AR and steroidogenesis enzyme expression after 3 months of androgen-deprivation therapy
por: Hamid, Agus Rizal A. H., et al.
Publicado: (2020)

The criminal gene: the link between MAOA and aggression (REVIEW)
por: Sohrabi, S
Publicado: (2015)

MED1 mediates androgen receptor splice variant induced gene expression in the absence of ligand
por: Liu, Gang, et al.
Publicado: (2014)

Epigenetic modification‐dependent androgen receptor occupancy facilitates the ectopic TSPY1 expression in prostate cancer cells
por: Leng, Xiangyou, et al.
Publicado: (2020)

Expression of AR-V7 (Androgen Receptor Variant 7) Protein in Granular Cytoplasmic Structures Is an Independent Prognostic Factor in Prostate Cancer Patients
por: König, Paul, et al.
Publicado: (2020)

A noncanonical AR addiction drives enzalutamide resistance in prostate cancer
por: He, Yundong, et al.
Publicado: (2021)

MAOA-a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells
por: Lin, Yi-Cheng, et al.
Publicado: (2017)

Somatic Alterations Impact AR Transcriptional Activity and Efficacy of AR-Targeting Therapies in Prostate Cancer
por: Chauhan, Gaurav, et al.
Publicado: (2021)

Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells
por: Shafi, Ayesha A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qa1t1frjn181pn2jfcr0emfemo