Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9(+) tracheal chondrocytes

Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are associated with tracheomalacia in patients and mou...

Descripción completa

Detalles Bibliográficos
Autores principales: Nasr, Talia, Holderbaum, Andrea M., Chaturvedi, Praneet, Agarwal, Kunal, Kinney, Jessica L., Daniels, Keziah, Trisno, Stephen L., Ustiyan, Vladimir, Shannon, John M., Wells, James M., Sinner, Debora, Kalinichenko, Vladimir V., Zorn, Aaron M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875488/
https://www.ncbi.nlm.nih.gov/pubmed/33328171
http://dx.doi.org/10.1242/dmm.046573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875488/
https://www.ncbi.nlm.nih.gov/pubmed/33328171
http://dx.doi.org/10.1242/dmm.046573

Ejemplares similares