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Sperm microRNAs confer depression susceptibility to offspring

Evidence that offspring traits can be shaped by parental life experiences in an epigenetically inherited manner paves a way for understanding the etiology of depression. Here, we show that F1 offspring born to F0 males of depression-like model are susceptible to depression-like symptoms at the molec...

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Autores principales: Wang, Yanbo, Chen, Zhang-Peng, Hu, Huanhuan, Lei, Jieqiong, Zhou, Zhen, Yao, Bing, Chen, Li, Liang, Gaoli, Zhan, Shoubin, Zhu, Xiaoju, Jin, Fangfang, Ma, Rujun, Zhang, Jun, Liang, Hongwei, Xing, Ming, Chen, Xiao-Rui, Zhang, Chen-Yu, Zhu, Jing-Ning, Chen, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875527/
https://www.ncbi.nlm.nih.gov/pubmed/33568480
http://dx.doi.org/10.1126/sciadv.abd7605
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author Wang, Yanbo
Chen, Zhang-Peng
Hu, Huanhuan
Lei, Jieqiong
Zhou, Zhen
Yao, Bing
Chen, Li
Liang, Gaoli
Zhan, Shoubin
Zhu, Xiaoju
Jin, Fangfang
Ma, Rujun
Zhang, Jun
Liang, Hongwei
Xing, Ming
Chen, Xiao-Rui
Zhang, Chen-Yu
Zhu, Jing-Ning
Chen, Xi
author_facet Wang, Yanbo
Chen, Zhang-Peng
Hu, Huanhuan
Lei, Jieqiong
Zhou, Zhen
Yao, Bing
Chen, Li
Liang, Gaoli
Zhan, Shoubin
Zhu, Xiaoju
Jin, Fangfang
Ma, Rujun
Zhang, Jun
Liang, Hongwei
Xing, Ming
Chen, Xiao-Rui
Zhang, Chen-Yu
Zhu, Jing-Ning
Chen, Xi
author_sort Wang, Yanbo
collection PubMed
description Evidence that offspring traits can be shaped by parental life experiences in an epigenetically inherited manner paves a way for understanding the etiology of depression. Here, we show that F1 offspring born to F0 males of depression-like model are susceptible to depression-like symptoms at the molecular, neuronal, and behavioral levels. Sperm small RNAs, and microRNAs (miRNAs) in particular, exhibit distinct expression profiles in F0 males of depression-like model and recapitulate paternal depressive-like phenotypes in F1 offspring. Neutralization of the abnormal miRNAs in zygotes by antisense strands rescues the acquired depressive-like phenotypes in F1 offspring born to F0 males of depression-like model. Mechanistically, sperm miRNAs reshape early embryonic transcriptional profiles in the core neuronal circuits toward depression-like phenotypes. Overall, the findings reveal a causal role of sperm miRNAs in the inheritance of depression and provide insight into the mechanism underlying susceptibility to depression.
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spelling pubmed-78755272021-02-19 Sperm microRNAs confer depression susceptibility to offspring Wang, Yanbo Chen, Zhang-Peng Hu, Huanhuan Lei, Jieqiong Zhou, Zhen Yao, Bing Chen, Li Liang, Gaoli Zhan, Shoubin Zhu, Xiaoju Jin, Fangfang Ma, Rujun Zhang, Jun Liang, Hongwei Xing, Ming Chen, Xiao-Rui Zhang, Chen-Yu Zhu, Jing-Ning Chen, Xi Sci Adv Research Articles Evidence that offspring traits can be shaped by parental life experiences in an epigenetically inherited manner paves a way for understanding the etiology of depression. Here, we show that F1 offspring born to F0 males of depression-like model are susceptible to depression-like symptoms at the molecular, neuronal, and behavioral levels. Sperm small RNAs, and microRNAs (miRNAs) in particular, exhibit distinct expression profiles in F0 males of depression-like model and recapitulate paternal depressive-like phenotypes in F1 offspring. Neutralization of the abnormal miRNAs in zygotes by antisense strands rescues the acquired depressive-like phenotypes in F1 offspring born to F0 males of depression-like model. Mechanistically, sperm miRNAs reshape early embryonic transcriptional profiles in the core neuronal circuits toward depression-like phenotypes. Overall, the findings reveal a causal role of sperm miRNAs in the inheritance of depression and provide insight into the mechanism underlying susceptibility to depression. American Association for the Advancement of Science 2021-02-10 /pmc/articles/PMC7875527/ /pubmed/33568480 http://dx.doi.org/10.1126/sciadv.abd7605 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Wang, Yanbo
Chen, Zhang-Peng
Hu, Huanhuan
Lei, Jieqiong
Zhou, Zhen
Yao, Bing
Chen, Li
Liang, Gaoli
Zhan, Shoubin
Zhu, Xiaoju
Jin, Fangfang
Ma, Rujun
Zhang, Jun
Liang, Hongwei
Xing, Ming
Chen, Xiao-Rui
Zhang, Chen-Yu
Zhu, Jing-Ning
Chen, Xi
Sperm microRNAs confer depression susceptibility to offspring
title Sperm microRNAs confer depression susceptibility to offspring
title_full Sperm microRNAs confer depression susceptibility to offspring
title_fullStr Sperm microRNAs confer depression susceptibility to offspring
title_full_unstemmed Sperm microRNAs confer depression susceptibility to offspring
title_short Sperm microRNAs confer depression susceptibility to offspring
title_sort sperm micrornas confer depression susceptibility to offspring
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875527/
https://www.ncbi.nlm.nih.gov/pubmed/33568480
http://dx.doi.org/10.1126/sciadv.abd7605
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