ATP citrate lyase inhibitor triggers endoplasmic reticulum stress to induce hepatocellular carcinoma cell apoptosis via p‐eIF2α/ATF4/CHOP axis

ATP citrate lyase (ACLY), a key enzyme in the metabolic reprogramming of many cancers, is widely expressed in various mammalian tissues. This study aimed to evaluate the effects and mechanisms of ACLY and its inhibitor BMS‐303141 on hepatocellular carcinoma (HCC). In this study, ACLY was highly expr...

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Detalles Bibliográficos
Autores principales: Zheng, Yihu, Zhou, Qingqing, Zhao, Chang, Li, Junjian, Yu, Zhengping, Zhu, Qiandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875901/
https://www.ncbi.nlm.nih.gov/pubmed/33393219
http://dx.doi.org/10.1111/jcmm.16235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875901/
https://www.ncbi.nlm.nih.gov/pubmed/33393219
http://dx.doi.org/10.1111/jcmm.16235

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