The HIF‐1α/p53/miRNA‐34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization

Wet age‐related macular degeneration (wAMD), characterized by choroidal neovascularization (CNV), is a leading cause of irreversible vision loss among elderly people in developed nations. Subretinal fibrosis, mediated by epithelial‐mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cel...

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Detalles Bibliográficos
Autores principales: Xie, Laiqing, Wang, Ying, Li, Quan, Ji, Xiaoyan, Tu, Yuanyuan, Du, Shu, Lou, Hui, Zeng, Xinwei, Zhu, Linling, Zhang, Ji, Zhu, Manhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875902/
https://www.ncbi.nlm.nih.gov/pubmed/33438362
http://dx.doi.org/10.1111/jcmm.16272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875902/
https://www.ncbi.nlm.nih.gov/pubmed/33438362
http://dx.doi.org/10.1111/jcmm.16272

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