PLCγ1 inhibition‐driven autophagy of IL‐1β‐treated chondrocyte confers cartilage protection against osteoarthritis, involving AMPK, Erk and Akt

Previous studies identified the involvement of phosphoinositide‐specific phospholipase C (PLC) γ1 in some events of chondrocytes. This study aims to investigate whether and how PLCγ1 modulates autophagy to execute its role in osteoarthritis (OA) progression. Rat normal or human OA chondrocytes were...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Xiaolei, Wang, Yue, Qu, Ning, Zhang, Bing, Xia, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875910/
https://www.ncbi.nlm.nih.gov/pubmed/33372388
http://dx.doi.org/10.1111/jcmm.16245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875910/
https://www.ncbi.nlm.nih.gov/pubmed/33372388
http://dx.doi.org/10.1111/jcmm.16245

Ejemplares similares