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PLCγ1 inhibition‐driven autophagy of IL‐1β‐treated chondrocyte confers cartilage protection against osteoarthritis, involving AMPK, Erk and Akt

Previous studies identified the involvement of phosphoinositide‐specific phospholipase C (PLC) γ1 in some events of chondrocytes. This study aims to investigate whether and how PLCγ1 modulates autophagy to execute its role in osteoarthritis (OA) progression. Rat normal or human OA chondrocytes were...

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Detalles Bibliográficos
Autores principales:	Chen, Xiaolei, Wang, Yue, Qu, Ning, Zhang, Bing, Xia, Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875910/ https://www.ncbi.nlm.nih.gov/pubmed/33372388 http://dx.doi.org/10.1111/jcmm.16245

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