Cargando…

Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells

Xanthatin (Xa) is a bicyclic sesquiterpene lactone identified from the plant Xanthium L. with impressive antitumor activity, but the role of Xa in non‐small cell lung cancer (NSCLC) is not known. Here we found that Xa inhibits proliferation, migration, invasion and induces apoptosis in NSCLC cells....

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jian, Yang, Sheng, Guan, Hongmei, Zhou, Jueyu, Gao, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875932/ https://www.ncbi.nlm.nih.gov/pubmed/33439503 http://dx.doi.org/10.1111/jcmm.16271

Ejemplares similares

Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases
por: Liu, Man, et al.
Publicado: (2019)

RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
por: Zhu, Qian, et al.
Publicado: (2021)

The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination
por: Fukuda, Takayo, et al.
Publicado: (2015)

Concerted Suppression of STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin
por: Tao, Li, et al.
Publicado: (2013)

The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination
por: Wu, Duo, et al.
Publicado: (2023)

VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases
por: Ekstrom, Thomas L., et al.
Publicado: (2021)

PALB2 or BARD1 loss confers homologous recombination deficiency and PARP inhibitor sensitivity in prostate cancer
por: Dillon, Kasia M., et al.
Publicado: (2022)

Inhibition of DNA-PK by gefitinib causes synergism between gefitinib and cisplatin in NSCLC
por: Pan, Chi, et al.
Publicado: (2020)

Xanthatin Induces Leishmanicidal Activity by Affecting Carbon Metabolism in Amastigotes
por: Akbari, Ziba, et al.
Publicado: (2021)

Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2-mediated STAT3/PI3K/Akt signaling pathway
por: Shen, Mei, et al.
Publicado: (2018)

A Novel Nanoparticle Preparation to Enhance the Gastric Adhesion and Bioavailability of Xanthatin
por: Zhou, Yaqian, et al.
Publicado: (2020)

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination in sister chromatids
por: Nakamura, Kyosuke, et al.
Publicado: (2019)

Xanthatin Alleviates LPS-Induced Inflammatory Response in RAW264.7 Macrophages by Inhibiting NF-κB, MAPK and STATs Activation
por: Liu, Yuanqi, et al.
Publicado: (2022)

Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis
por: Shi, Lewis Zhichang, et al.
Publicado: (2021)

Xanthatin Selectively Targets Retinoblastoma by Inhibiting the PLK1-Mediated Cell Cycle
por: Yang, Jie, et al.
Publicado: (2021)

Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer
por: Ozden, Ozkan, et al.
Publicado: (2016)

Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity
por: Adamovich, Aleksandra I., et al.
Publicado: (2019)

BARDES coming of age?
Publicado: (2022)

KLF4 suppresses the proliferation and metastasis of NSCLC cells via inhibition of MSI2 and regulation of the JAK/STAT3 signaling pathway
por: Luo, Di-Di, et al.
Publicado: (2022)

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
por: Boyle, D L, et al.
Publicado: (2015)

Sulforaphane regulates apoptosis- and proliferation-related signaling pathways and synergizes with cisplatin to suppress human ovarian cancer
por: Kan, Shi-Feng, et al.
Publicado: (2018)

Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signaling
por: You, Xiaolan, et al.
Publicado: (2022)

Xanthatin suppresses proliferation and tumorigenicity of glioma cells through autophagy inhibition via activation of the PI3K‐Akt–mTOR pathway
por: Chen, Huaqing, et al.
Publicado: (2022)

Piperlongumine Induces Apoptosis and Synergizes with Doxorubicin by Inhibiting the JAK2-STAT3 Pathway in Triple-Negative Breast Cancer
por: Chen, Di, et al.
Publicado: (2019)

JAKs and STATs in chemoresistance
por: Costa-Pereira, Ana P
Publicado: (2010)

JAK-STAT and feeding
por: Ladyman, Sharon R., et al.
Publicado: (2013)

Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
por: Romero, M., et al.
Publicado: (2015)

Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability
por: Pilyugin, Maxim, et al.
Publicado: (2016)

Synergism Antiproliferative Effects of Apigenin and Naringenin in NSCLC Cells
por: Liu, Xiongxiong, et al.
Publicado: (2023)

Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway
por: Malemud, Charles J.
Publicado: (2010)

C9ORF72 suppresses JAK-STAT mediated inflammation
por: Pang, Weilun, et al.
Publicado: (2023)

Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells
por: Mani, Chinnadurai, et al.
Publicado: (2019)

Dualistic Role of BARD1 in Cancer
por: Cimmino, Flora, et al.
Publicado: (2017)

(–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin
por: Takeda, Shuso, et al.
Publicado: (2022)

BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1
por: Witus, Samuel R., et al.
Publicado: (2021)

The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology
por: Sims, Natalie A.
Publicado: (2020)

Homologous recombination mRNAs (RAD21, RAD50 and BARD1) have a potentially poor prognostic role in ERBB2-low bladder cancer patients
por: Albarakati, Nada, et al.
Publicado: (2023)

Cisplatin and CCNU synergism in spheroid cell subpopulations.
por: Durand, R. E.
Publicado: (1990)

Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival
por: Dai, Chun-Hua, et al.
Publicado: (2016)

A JAK/STAT invasion
por: Wells, William A.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_dfdupnbbrbh6g15ejd5pgbis8o