Cargando…

Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA

Actinobacteria are among the most prolific sources of medically and agriculturally important compounds, derived from their biosynthetic gene clusters (BGCs) for specialized (secondary) pathways of metabolism. Genomics witnesses that the majority of actinobacterial BGCs are silent, most likely due to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yushchuk, Oleksandr, Ostash, Iryna, Mösker, Eva, Vlasiuk, Iryna, Deneka, Maksym, Rückert, Christian, Busche, Tobias, Fedorenko, Victor, Kalinowski, Jörn, Süssmuth, Roderich D., Ostash, Bohdan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875965/ https://www.ncbi.nlm.nih.gov/pubmed/33568768 http://dx.doi.org/10.1038/s41598-021-82934-6

Ejemplares similares

Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin
por: Makitrynskyy, Roman, et al.
Publicado: (2013)

Heterologous Expression Reveals Ancient Properties of Tei3—A VanS Ortholog from the Teicoplanin Producer Actinoplanes teichomyceticus
por: Yushchuk, Oleksandr, et al.
Publicado: (2022)

Decoding options and accuracy of translation of developmentally regulated UUA codon in Streptomyces: bioinformatic analysis
por: Rokytskyy, Ihor, et al.
Publicado: (2016)

Insights into naturally minimised Streptomyces albus J1074 genome
por: Zaburannyi, Nestor, et al.
Publicado: (2014)

Properties of Multidrug-Resistant Mutants Derived from Heterologous Expression Chassis Strain Streptomyces albidoflavus J1074
por: Dolya, Borys, et al.
Publicado: (2023)

Genome-wide Distribution of AdpA, a Global Regulator for Secondary Metabolism and Morphological Differentiation in Streptomyces, Revealed the Extent and Complexity of the AdpA Regulatory Network
por: Higo, Akiyoshi, et al.
Publicado: (2012)

Role of GntR Family Regulatory Gene SCO1678 in Gluconate Metabolism in Streptomyces coelicolor M145
por: Tsypik, Olga, et al.
Publicado: (2017)

AdpA, key regulator for morphological differentiation regulates bacterial chromosome replication
por: Wolański, Marcin, et al.
Publicado: (2012)

AdpA Positively Regulates Morphological Differentiation and Chloramphenicol Biosynthesis in Streptomyces venezuelae
por: Płachetka, Małgorzata, et al.
Publicado: (2021)

Identified members of the Streptomyces lividans AdpA regulon involved in differentiation and secondary metabolism
por: Guyet, Aurélie, et al.
Publicado: (2014)

The Pleiotropic Regulator AdpA Regulates the Removal of Excessive Sulfane Sulfur in Streptomyces coelicolor
por: Lu, Ting, et al.
Publicado: (2023)

AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomycesalbulus
por: Huang, Rui, et al.
Publicado: (2022)

AdpA(lin), a Pleiotropic Transcriptional Regulator, Is Involved in the Cascade Regulation of Lincomycin Biosynthesis in Streptomyces lincolnensis
por: Kang, Yajing, et al.
Publicado: (2019)

Global Regulator AdpA_1075 Regulates Morphological Differentiation and Ansamitocin Production in Actinosynnema pretiosum subsp. auranticum
por: Guo, Siyu, et al.
Publicado: (2022)

Properties of Spontaneous rpsL Mutant of Streptomyces albus KO-1297
por: Shemediuk, A. L., et al.
Publicado: (2022)

Sulfane Sulfur Posttranslationally Modifies the Global Regulator AdpA to Influence Actinorhodin Production and Morphological Differentiation of Streptomyces coelicolor
por: Lu, Ting, et al.
Publicado: (2022)

Genome Sequence-Guided Finding of Lucensomycin Production by Streptomyces achromogenes Subsp. streptozoticus NBRC14001
por: Nishimura, Sho, et al.
Publicado: (2021)

Regulation of morphological differentiation in S. coelicolor by RNase III (AbsB) cleavage of mRNA encoding the AdpA transcription factor
por: Xu, Weijing, et al.
Publicado: (2010)

Preconditioning of the YSZ-NiO Fuel Cell Anode in Hydrogenous Atmospheres Containing Water Vapor
por: Vasyliv, Bogdan, et al.
Publicado: (2017)

Class II two-peptide lanthipeptide proteases: exploring LicTP for biotechnological applications
por: Barbosa, Joana C., et al.
Publicado: (2023)

Bidirectional Regulation of AdpA(ch) in Controlling the Expression of scnRI and scnRII in the Natamycin Biosynthesis of Streptomyces chattanoogensis L10
por: Yu, Pin, et al.
Publicado: (2018)

Flavacol and Its Novel Derivative 3-β-Hydroxy Flavacol from Streptomyces sp. Pv 4-95 after the Expression of Heterologous AdpA
por: Tistechok, Stepan, et al.
Publicado: (2022)

Coupling of the engineered DNA “mutator” to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces
por: Sekurova, Olga N, et al.
Publicado: (2021)

Influence of Treatment Temperature on Microstructure and Properties of YSZ–NiO Anode Materials
por: Podhurska, Viktoriya, et al.
Publicado: (2016)

Oxidation Resistance of Materials Based on Ti(3)AlC(2) Nanolaminate at 600 °C in Air
por: Ivasyshyn, Andrij, et al.
Publicado: (2016)

11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain
por: Shaaban, Khaled A., et al.
Publicado: (2010)

Occurrence of vanHAX and Related Genes beyond the Actinobacteria Phylum
por: Yushchuk, Oleksandr, et al.
Publicado: (2022)

Genetics Behind the Glycosylation Patterns in the Biosynthesis of Dalbaheptides
por: Yushchuk, Oleksandr, et al.
Publicado: (2022)

Genomic Insights into the Distribution and Phylogeny of Glycopeptide Resistance Determinants within the Actinobacteria Phylum
por: Andreo-Vidal, Andrés, et al.
Publicado: (2021)

Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by Nonomuraea coxensis DSM 45129
por: Yushchuk, Oleksandr, et al.
Publicado: (2021)

The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis
por: Schoppet, Melanie, et al.
Publicado: (2018)

Modulations of SIR-nucleosome interactions of reconstructed yeast silent pre-heterochromatin by O-acetyl-ADP-ribose and magnesium
por: Tung, Shu-Yun, et al.
Publicado: (2017)

Matters of class: coming of age of class III and IV lanthipeptides
por: Hegemann, Julian D., et al.
Publicado: (2020)

Identification of the Catalytic Residues in the Cyclase Domain of the Class IV Lanthipeptide Synthetase SgbL
por: Hegemann, Julian D., et al.
Publicado: (2021)

136th SPSC Meeting
Publicado: (2019)

136th LHCC Meeting
Publicado: (2018)

P136 Vegan orthopaedics
por: Silk, Gwithyen, et al.
Publicado: (2021)

The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms
por: Reen, F. Jerry, et al.
Publicado: (2015)

Activation of silent biosynthetic gene clusters using transcription factor decoys
por: Wang, Bin, et al.
Publicado: (2018)

Loss of famh-136/ FAM136A results in minor locomotion and behavioral changes in Caenorhabditis elegans
por: Tan, Chieh-Hsiang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gfo2ki129i8ijejqc357s8edor